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HOME > 研究論文・業績 > 論文 応用発生工学先端研究所 長嶋 比呂志

研究論文・業績

応用発生工学先端研究所 長嶋 比呂志 論文

Nakano K, Watanabe M, Matsunari H, Matsuda T, Honda K, Maehara M, Kanai T, Hayashida G, Kobayashi M, Kuramoto M, Arai Y, Umeyama K, Fujishiro S, Mizukami Y, Nagaya M, Hanazono Y, Nagashima H: Generating porcine chimeras using inner cell mass cells and parthenogenetic preimplantation embryos. PLOS ONE, 2013,DOI: 10.1371/journal.pone.0061900.
Ikeda K, Yamamoto A, Nanjo A, Inuinaka C, Takama Y, Ueno T, Fukuzawa M, Nakano K, Matsunari H, Nagashima H, Miyagawa S: A cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase from porcine endothelial cells. Transplantation Proceedings 2012, 44(4):1136-1138,DOI: 10.1016/j.transproceed.2012.01.092.
Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg L.A., Nakauchi H. (2013) Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proc Natl Acad Sci U S A 110:4557-62. DOI: 1222902110 [pii]10.1073/pnas.1222902110.
Fujishiro S.H., Nakano K., Mizukami Y., Azami T., Arai Y., Matsunari H., Ishino R., Nishimura T., Watanabe M., Abe T., Furukawa Y., Umeyama K., Yamanaka S., Ema M., Nagashima H., Hanazono Y. (2013) Generation of naive-like porcine-induced pluripotent stem cells capable of contributing to embryonic and fetal development. Stem Cells Dev 22:473-82. DOI: 10.1089/scd.2012.0173.
Klymiuk N., van Buerck L., Bahr A., Offers M., Kessler B., Wuensch A., Kurome M., Thormann M., Lochner K., Nagashima H., Herbach N., Wanke R., Seissler J., Wolf E. (2012) Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice. Diabetes 61:1527-32. DOI: db11-1325 [pii]10.2337/db11-1325.
Matsumoto K., Yokoo T., Matsunari H., Iwai S., Yokote S., Teratani T., Gheisari Y., Tsuji O., Okano H., Utsunomiya Y., Hosoya T., Okano H.J., Nagashima H., Kobayashi E. (2012) Xenotransplanted embryonic kidney provides a niche for endogenous mesenchymal stem cell differentiation into erythropoietin-producing tissue. Stem Cells 30:1228-35. DOI: 10.1002/stem.1101.
Nakatsu S., Takama Y., Ueno T., Inuinaka C., Takeishi S., Kondo A., Okitsu T., Nagashima H., Fukuzawa M., Miyagawa S. (2012) A study of the glycoantigens of neonatal porcine islet-like cell clusters using a lectin microarray. Transplant Proc 44:1134-5. DOI: S0041-1345(12)00239-4 [pii]10.1016/j.transproceed.2012.03.019.
Richter A., Kurome M., Kessler B., Zakhartchenko V., Klymiuk N., Nagashima H., Wolf E., Wuensch A. (2012) Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig. BMC Biotechnol 12:84. DOI: 1472-6750-12-84 [pii]10.1186/1472-6750-12-84.
Konishi T, Takahashi S, Zhuang Z, Nagata K, Mizumoto M, Honda M, Takeuchi Y, Matsunari H, Nagashima H, Aizawa M: Biodegradable β-Tricalcium Phosphate Cement with Anti- washout Property Based on Chelate-setting Mechanism of Inositol Phosphate. Journal of Materials Science: Materials in Medicine, DOI: 10.1007/s 10856-013-4903-8, 2013.
Walters EM, Wolf E, Whyte JJ, Mao J, Renner S, Nagashima H, Kobayashi E, Zhao J, Wells KD, Critser JK, Riley LK, Prather RS: Completion of the swine genome will simplify the production of swine as a large animal biomedical model. BMC Medical Genomics, 5(55), 2012.
Renner S, Braun C, Blutke A, Herbach N, Emrich D, Streckel E, Wunsch A, Kessler B, Kurome M, Bahr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J, Blum H, Wanke R, Wolf E: Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs. Diabetes ,DOI: db12-1065 [pii] 10.2337/db12-1065, 2012.
Matsunari H, Maehara M, Nakano K, Ikezawa Y, Hagiwara Y, Sasayama N, Shirasu A, Ohta H, Takahashi M, Nagashima H: Hollow fiber vitrification: A novel method for vitrifying multiple embryos in a single device. Journal of Reproduction and Development, 58:599-608, 2012.
Maehara M, Matsunari H, Honda K, Nakano K, Takeuchi H, Kanai T, Matsuda T, Matsumura Y, Hagiwara Y, Sasayama N, Shirasu A, Takahashi M, Watanabe M, Umeyama K, Hanazono Y, Nagashima H: Hollow Fiber Vitrification Provides a Novel Method for Cryopreserving In Vitro Maturation/Fertilization-Derived Porcine Embryos. Biology of Reproduction,DOI: biolreprod.112.100339, 2012.
Teratani T, Matsunari H, Kasahara N, Nagashima H, Kawarasaki T, Kobayashi E: Islets from rats and pigs transgenic for photogenic proteins. Current Diabetes Reviews, 8:382-389,CDR-EPUB-20120514-20 [pii]、2012.
Miyagawa S, Maeda A, Takeishi S, Ueno T, Usui N, Matsumoto S, Okitsu T, Goto M, Nagashima H: A Lectin array analysis for wild-type and a-Gal-knockout pig islets, compared with humans. Surgery Today 2012, in press.
Umeyama K, Saito H, Kurome M, Matsunari H, Watanabe M, Nakauchi H, Nagashima H: Characterization of the ICSI-mediated gene transfer method in the production of transgenic pigs. Molecular Reproduction and Development, 79:218-228, 2012.
Sahara H, Nagashima H, Sekijima M, Tasaki M, Setoyama K, Matsunari H, Nakano K, Date H, Shimizu A, Yamada K: Prevention of hyper-acute pulmonary xenograft dysfunction using GalT-KO swine in an ex-vivo lung perfusion model. Xenotransplantation, 18(5):299, 2012.
Kemter E, Lieke T, Kessler B, Kurome M, Wuensch A, Summerfield A, Ayares D, Nagashima H, Baars W, Schwinzer R, Wolf E: Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses. Xenotransplantation,19: 40-51, 2011.
Watanabe M, Kurome M, Matsunari H, Nakano K, Umeyama K, Shiota A, Nakauchi H, Nagashima H: The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer. Transgenic Research 21(3):605-618, DOI:10.1007/s11248-011-9561-3, 2011.
Klymiuk N, Böcker W, Schönitzer V, Bähr A, Radic T, Fröhlich T, Wünsch A, Keßler B, Kurome M, Schilling E, Herbach N, Wanke R, Nagashima H, Mutschler W, Arnold G.J, Schwinzer R, Schieker M, Wolf E: First inducible transgene expression in porcine large animal models. The FASEB Journal, 26: 1086-1099, 2011.
Klymiuk N, Mundhenk L, Kraehe K, Wuensch A, Plog S, Emrich D, Langenmayer MC, Stehr M, Holzinger A, Kroner C, Richter A, Kessler B, Kurome M, Eddicks M, Nagashima H, Heinritzi K, Gruber A.D, Wolf E: Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis. Journal of Molecular Medicine, DOI:10.1007/s00109-011-0839-y, 2011.
Tomii R, Ogawa B, Imai Y, Hanada Y, Sasayama N, Shirasu A, Nagashima H: In vitro development and post-vitrification survival of cloned feline embryos derived from preadipocytes. Journal of Reproduction and Development, 57: 273-279, 2011.
Nakano K, Matsunari H, Nakayama N, Ogawa B, Kurome M, Takahashi M, Matsumoto M, Murakami H, Kaji Y, Nagashima H. Cloned porcine embryos can maintain developmental ability after cryopreservation at the morula stage. Journal of Reproduction and Development, 57: 312-316, 2011.
Umeyama K, Kawano H, Kurome M, Matsunari H, Watanabe M, Nagashima H. Comparison of transgene expression patterns in mouse embryos following ICSI-mediated gene transfer or pronuclear microinjection. Bulletin of School of Agriculture, Meiji University 60:13-19, 2010,.
Ogawa B, Ueno S, Nakayama N, Matsunari H, Nakano K, Fujiwara T, Ikezawa Y, Nagashima H. Developmental ability of porcine in vitro matured oocytes at the meiosis II stage after vitrification. Journal of Reproduction and Development, 56:356-361, 2010.
Miyagawa S, Takeishi S, Yamamoto A, Ikeda K, Matsunari H, Yamada M, Okabe M, Miyoshi E, Fukuzawa M, Nagashima H. Survey of glycoantigens in cells from alpha1-3galactosyltransferase knockout pig using a lectin microarray. Xenotransplantation, 17:61-70, 2010.
落合恵子, 池田有希, 香川則子, 桑田正成, 長嶋比呂志: 老化促進モデルマウスSAMP1亜系統の生理・病理学的特徴の解析.明治大学農学部研究報告, 59:103-107, 2010.
Watanabe M, Umeyama K, Matsunari H, Takayanagi S, Haruyama E, Nakano K, Fujiwara T, Ikezawa Y, Nakauchi H, Nagashima H: Knockout of exogenous EGFP gene in porcine somatic cells using zink-finger nucleases. Biochemical and Biophysical Research Communications, 402:14-18, 2010.
Umeyama K, Watanabe M, Saito H, Kurome M, Tohi S, Matsunari H, Miki H, Nagashima H: Dominant t-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs. Transgenic Research, 18(5):697-706, 2009.
Tomii R, Kurome M, Wako N, Ochiai T, Matsunari H, Kano K, Nagashima H: Production of cloned pigs by nuclear transfer of preadipocytes following cell cycle synchronization by differentiation induction. Journal of Reproduction and Development, 55:121-127, 2009.
Kasai T, Kano H, Umeda Y, Sasaki T, Ikawa N, Nishizawa T, Nagano K, Arito H, Nagashima H, Fukushima H: Two-year inhalation study of carcinogenicity and chronic toxicity of 1,4-dioxane in male rats. Inhalation Toxicology, 21:889-897, 2009.
Fujimura T, Nagashima H.他4名(最終) Effects of recloning on the efficiency of production of α1,3-galactosyltransferase - knockout pigs.Journal of Reproduction and Development.54: 58-62,2008
Fujimura T, Nagashima H,他5名(4番目) Production of alpha 1,3-galactosyltransferase gene-deficient pigs by somatic cell nuclear transfer: a novel selection method for gal alpha 1,3-Gal antigen-deficient cells. Molecular Reproduction and Development. 75: 1372-1378,2008
Kurome M, Nagashima H.他10名(最終) Production efficiency and telomere length of the cloned pigs following serial somatic cell nuclear transfer. Journal of Reproduction and Development.54: 254-258,2008
Kurome M, Nagashima H.他5名(最終) Production of transgenic and non-transgenic clones in miniature pigs by somatic cell nuclear transfer. Journal of Reproduction and Development.54: 156-163,2008
Kurome M, Nagashima H.他9名(最終) Production of cloned pigs from salivary gland-derived progenitor cells. Cloning and Stem Cells.10: 277-285,2008
Matsunari H, Nagashima H.他10名(最終) Transgenic-cloned pigs systemically expressing red fluorescent protein, kusabira-orange. Cloning and Stem Cells. 10: 313-324,2008
Kurome M, Nagashima H.他4名(最終) Effects of sperm pretreatment on efficiency of ICSI-mediated gene transfer in pigs. Journal of Reproduction and Development. 53: 1217-1226,2007
Nagashima H, 他7名(筆頭) Production of live piglets following cryopreservation of embryos derived from in vitro-matured oocytes. Biology of Reproduction. 76: 900-905,2007
Ueno S, Nagashima H.他4名(最終) Association between embryonic loss and damage to the zona pellucida by invasive micromanipulation during oviductal transfer of early-stage embryos in pigs. Journal of Reproduction and Development. 53: 1113-1118,2007
Watanabe M, Nagashima H,他4名(5番目) The production of a diabetic mouse using constructs encoding porcine insulin promoter-driven mutant human hepatocyte nuclear factor-1 alpha. J Reprod Dev.53: 189-200,2007
Kurome M, Nagashima H. 他3名(最終)Production of transgenic-clone pigs by the combination of ICSI-mediated gene transfer with somatic cell nuclear transfer. Transgenic Research. 15: 229-240,2006
Shimada A, Nagashima H.他2名(最終) Transplantation and differentiation of donor cells in the cloned pigs. Biochemical and Biophysical Research Communications.344: 455-462,2006
Miyazaki K, Nagashima H.他6名(最終) Evaluation of the quality of porcine somatic cell nuclear transfer embryos by gene transcription profiles. Journal of Reproduction and Development. 51: 123-131,2005.
Naruse K, Nagashima H,他8名(9番目) Production of a transgenic pig expressing human albumin and enhanced green fluorescent protein. Journal of Reproduction and Developemnt. 71: 539-546,2005
Naruse K, Nagashima H,他3名(2番目) Development and perspectives of perfusion treatment for liver failure. Surg Today.35: 507-517,2005
Ogonuki N, Nagashima H,他8名(9番目) Ogura A. Differential development of rabbit embryos following microinsemination with sperm and spermatids. Molecular Reproduction and Development. 72: 411-417,2005
Takahagi Y, Nagashima H,他5名(4番目) Production of α1,3-galactosyltransferase gene knockout pigs expressing both human decay-accelerating factor and N-acetylglucosaminyltransferase III. Molecular Reproduction and Development. 71: 331-338,2005
Tomii R, Nagashima H.他6名(最終) Production of cloned pigs by nuclear transfer of preadipocytes established from adult mature adipocytes. Cloning and Stem Cells. 7: 279-288,2005
Ueno S, Nagashima H.他4名(最終) Effects of maturation conditions on spindle morphology in porcine MII oocytes. Journal of Reproduction and Developemnt. 51: 405-410,2005
Esaki R, Nagashima H.他7名(最終) Cryopreservation of porcine embryos derived from in vitro matured oocytes. Biology of Reproduction. 71: 432-437,2004
Fujimura T, Nagashima H.他8名(最終) Cloning of the transgenic pigs expressing human decay accelerating facor and N-acetylglucosaminyltransferase III. Cloning and Stem Cells. 6: 294-301,2004
Miki H, Nagashima H,他5名(5番目) Cytoplasmic asters are required for progression past the first cell cycle in cloned mouse embryos. Biology of Reproduction. 71: 2022-2028,2004
Ushijima H, Nagashima H.他5名(最終) Improved survival of vitrified in vivo-derived porcine embryos. Journal of Reproduction and Development. 50: 481-486,2004

著書

  • Matsunari H, Watanabe M, Umeyama K, Nakano K, Ikezawa Y, Kurome M, Kessler B, Wolf E, Miyagawa S, Nakauchi H, Nagashima H: Chapter 3: Cloning of homozygous α1,3-galactosyltransferase gene knock-out pigs by somatic cell nuclear transfer. In: Xenotransplantation. Edited by Miyagawa S. InTech, Rijeka, Croatia 2012.
  • Nagashima H, Matsunari H, Umeyama K: Creation and conservation of genetically modified pigs: applications to genetic disease model and xenotransplantation. In: The Minipig in Biomedical Research. Edited by Mcanulty A.M, Dayan A.D, Ganderup N.C, p.415-430, CRC Press,Boca Raton, Fl, USA; 2011.
  • Kemter E, Lieke T, Kessler B, Kurome M, Wuensch A, Summerfield A, Ayares D, Nagashima H, Baars W, Schwinzer R, Wolf E.: Human TRAIL expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses. In: Xenotransplantation. Wiley Blackwell; 2011
  • Nagashima H, Matsunari H, Umeyama K: Creation and conservation of genetically modified pigs: applications to genetic disease model and xenotransplantation. In: The Minipig in Biomedical Research. CRC Press; 2011.
  • デザイナー・ピッグの基礎医学研究への応用. シリーズ21世紀の農学.動物・微生物の遺伝子工学研究. 日本農学会編.養賢堂,東京:129‐147,2007